DOI:https://onlinelibrary.wiley.com/doi/10.1111/acel.70603 Schematic diagram of the mechanism by which LINC01021 promotes cellular and individual aging.

The lamprey occupies a pivotal position for elucidating vertebrate brain evolution. Using spatial transcriptomics and single-nucleus RNA sequencing, we generated a three-dimensional molecular atlas of the lamprey brain, identifying 209 distinct cell clusters across 14 regions. Cross-species comparisons revealed broad conservation of regional spatial architecture, defining an ancestral organizational blueprint. Within this conserved framework, however, marked lineage-specific divergence emerged. We observed extensive neuronal specialization across vertebrate lineages, accompanied by regulatory shifts associated with spatial reorganization and functional diversification of neuronal populations. Additionally, our results suggest that a cerebellum-like architecture predates the jawed vertebrate cerebellum. Together, these findings identified constraints on neural organization and detected cellular innovations driving evolutionary diversification.

The Project of Financial Funds of the Ministry of Agriculture and Rural Affairs:Investigation of Fishery Resources and Habitat in the Pearl River Basin.

A research team from the Kunming Institute of Zoologyof the Chinese Academy of Sciences has demonstrated for the first time in non-human primates that auditory stimulation at 40 Hz significantly elevates β-amyloid levels in the cerebrospinal fluidof aged rhesus monkeys.